An advanced injectable treatment designed to repair skin, improve texture, and restore healthier, more radiant-looking skin.
Looking to improve skin quality, reduce fine lines, or restore damaged skin? Polynucleotides (PDRN) therapy is an advanced injectable treatment that stimulates cellular repair and boosts skin regeneration. At Kandhari Dermatology, this treatment is customised to improve skin texture, enhance hydration, and restore smoother, firmer, and more radiant skin over time.

Polynucleotides (PDRN) for wrinkles and fine lines work by stimulating the skin’s fibroblast cells to regenerate collagen, elastin, and the extracellular matrix — the structural scaffolding of the skin. As skin ages, fibroblast activity declines and this scaffolding degrades, leading to the formation of fine lines, loss of elasticity, and a hollowed, aged appearance. PDRN injections reverse this process at a cellular level by activating adenosine receptors that directly stimulate fibroblast proliferation and skin repair. The result is progressive improvement in skin quality, elasticity, fine lines, and overall youthful appearance — achieved through the skin’s own regenerative capacity rather than external volume addition.
PDRN is suitable for individuals with fine lines, loss of skin elasticity, skin laxity, or a crepey skin texture seeking a regenerative approach to anti-ageing. It is appropriate for all skin types and tones and is particularly suited to patients who prefer a biological, non-volumising treatment. PDRN is also a valuable complement to other anti-ageing treatments such as botulinum toxin, fillers, or CO2 laser.
PDRN stimulates natural collagen and elastin production, improving skin elasticity, fine line depth, and overall skin quality over successive sessions. The treatment improves skin hydration and regenerates the dermal matrix, restoring a more youthful skin architecture. Results are progressive and natural, with no risk of over-correction or volumisation.
Avoid blood-thinning medications and supplements for one week before treatment. Inform your dermatologist of any known fish allergies before treatment. A gentle skincare routine and consistent sun protection should be maintained in the period leading up to your sessions.
A topical anaesthetic is applied before the procedure for comfort. PDRN is administered through a series of microinjections into the target treatment area. The procedure takes approximately 20–30 minutes. Patients typically experience only mild pinching sensations during treatment.
Mild redness, swelling, or small bumps at injection sites are expected and typically resolve within 24–48 hours. Apply a gentle moisturiser and broad-spectrum sunscreen. Avoid vigorous exercise and direct sun exposure for 24 hours after treatment. Progressive improvement in skin quality will develop over multiple sessions.
PDRN has an excellent safety and tolerability profile. Temporary redness or mild swelling at injection points are the most common effects and resolve quickly. The treatment is highly biocompatible due to its salmon-derived polynucleotide base.
The cost varies based on the number of sessions and the amount of product required. A personalised treatment plan and pricing will be discussed at your consultation with Dr. Rajat Kandhari.
Looking for a natural approach to fine line treatment in Delhi? Book a consultation with Dr. Rajat Kandhari for Polynucleotide (PDRN) therapy — a regenerative injectable treatment that rebuilds skin architecture and improves elasticity from within. An ideal standalone or combination treatment for patients seeking progressive, natural anti-ageing results without volumisation.
Polynucleotides are biostimulators that rebuild the skin's own structural proteins over time, whereas HA fillers provide immediate volume. PDRN works through regeneration rather than replacement.
Typically three to four sessions spaced two to four weeks apart, followed by maintenance treatments every six months as advised by your dermatologist.
A topical anaesthetic is applied before treatment. Most patients experience only mild pinching during the microinjections.
Yes. PDRN complements botulinum toxin by addressing fine line quality and skin texture while the neurotoxin manages dynamic muscle-related lines.
Progressive improvement in skin quality, elasticity, and fine line appearance develops over several weeks after each session, with optimal results visible after completing the full course.
Results can last six months or more with a full course of treatment. Regular maintenance sessions sustain and build upon results over time.
Minimal. Most patients experience mild swelling or occasional bruising that resolves within a few days. Daily activities can usually be resumed the same day.
Dr. Rajat Kandhari uses evidence-based PDRN protocols and precise injection technique to deliver safe, effective, and progressive regenerative anti-ageing treatment tailored to each patient's skin profile.
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